Data Sheet


Proanthocynanidin Antioxidant Supplement

"Article on Green Tea"


Proancynol Proancynol is a combination of three sources of a group of molecules that are collectively referred to as oligomers of proanthocyanidins. These OPCs, as they are known for short, offer some of the most powerful antioxidant activity that has been identified to date. This antioxidant activity, in turn, offers users of OPC products a number of health benefits. AIM's Proancynoltm is a combination of OPCs derived from grape seed, pine bark, and green tea extracts.

To understand how OPCs work requires a short lesson in chemistry. To begin with, OPCs are all antioxidants, molecules that can neutralize free radicals, rogue molecules that cause damage at the cellular level.

The next question, then, is "What's an antioxidant, and what is a free radical?" Largely free radicals are highly reactive forms of oxygen that cause damage to cells throughout the body. Their effects can be seen everywhere from wrinkled skin to several forms of cancer and also heart disease. As your body creates energy at the cellular level, oxygen is metabolized, changing its structure. In this process, the oxygen molecule loses one electron, turning it into a free radical. Losing one electron makes the oxygen molecule highly reactive, sending it on a search for a new electron that it can steal. This highly reactive form of oxygen steals an electron from a molecule in a cell wall, triggering a chain reaction that creates a new free radical. A chain reaction begins. This constant string of free radical reactions begins to break down the cell membranes, creating a greater chance of contracting cancer and other diseases. Antioxidants are unique molecules that are able to neutralize free radicals before they do their damage. They stop the damage caused by free radicals by giving up an electron and returning the oxygen atom to its stable molecular configuration.

OPCs are particularly effective because they are "sacrifical antioxidants." This means that, upon ingestion, OPCs will sacrifice them selves in order to neutralize harmful free radicals within the body. When they have used themselves up, the OPC is then eliminated. For this reason, increased intake of OPCs only increases their beneficial effects. Another benefit of OPCs is that they spare other antioxidants. Free radicals must be neutralized by the body. Several substances, including vitamins C and E, as well as selenium, are able to stop free radicals before they do their damage. But, these vitamins and minerals are also needed for other vital functions in the body. Because OPCs are such effective antioxidants, they spare vitamins E and C from having to act as antioxidants, allowing these nutrients to perform their other functions in the body


The term proanthocyanidins refers to a class of substances. Within this chemical group are several chemically similar molecules. Research has identified four main OPCs. The most basic form is called a epichatechin (referred to as EC).

From here, OPCs are made more and more complex by the addition of a molecular structure known as a "gallo group." Thus, if a gallo group is added to a basic epicatechin molecule, the resulting new molecule is called an epigallocatechin (EGC).

As additional gallo groups are added, the molecule becomes more and more complex: Epicatechin gallate (ECG).

The most complex form of proanthocyanidin is called epigallocatechin gallate (EGCG).

Each of these molecules is an increasingly potent antioxidant. That is, EC cannot neutralize as many free radicals as EGC, which can't neutralize as many free radicals as ECG, and so on. It makes sense then that both researchers studying OPCs and marketers selling them would focus on the content of EGCG, since it is the most potent antioxidant.

This debate, about EGCG content has been one of the greatest causes of misinformation about OPC products. Grape seed proponents, for example, claim that pine bark doesn't contain any EGCG, which is their argument for why grape seed extracts are a better product than pine bark products.

In fact, it would be unlikely to find that pine hark doesn't contain EGCG. All plants that have been studied for their OPC content have been found to contain a mixture of all four forms of the substance. For pine bark to not contain EGCG would make it unique to the plant world. This isn't impossible; it just isn't very probable.

The truth is that most of the research done on pine bark was done before the subgroups of OPCs had been identified. It wasn't until later, when attention had turned to grape seed, that researchers identified these substances.

In addition, if EGCG were the only contributing factor to the value of an OPC product, products made from extracts of green tea would clearly be judged the best. The content of EGCG in grape seed is typically 15% of the total OPCs that are present. In the case of green tea extracts, the amount of EGCG is 50%. So, if the comparison is between pure products (made only of either pine bark, grape seed, or green tea extract) the product made from green tea will have the greatest antioxidant potential, and could thus be judged the best product.

OPC products, however, should not be evaluated strictly on their content of EGCG. The other OPC forms - EC, EGC, ECG - provide their own unique benefits. So, although it is true that in some research, EGCG has been found to be many times more effective than the other three OPCs, in other situations, it is less effective. For example, in tests on the effects of OPCs on reducing blood pressure, EGCG was found to be 15 times less effective than ECG. In tests investigating OPC's ability to destroy bacteria, EGCG was most effective at inhibiting some bacteria, but less effective inhibiting others.

So, while EGCG content is important (it does have the most powerful antioxidant activity), it is not the only consideration. The levels of the other catechins should also be considered when evaluating the effectiveness of a proanthocyanidin product. This is why Proancynol contains a combination of all three of the major sources of OPCs. It contains 15% pine bark extract, 15% grape seed extract, and 70% green tea extract. This ensures that it will have the highest levels of EGCG, while also maintaining a balanced profile of the three other catechins - EC, EGC, and ECG.


When first taking AIM Proancynol™, the recommended serving is to take lmg of active ingredient per pound of body weight. So, for example, a person weighing 160 pounds would take four AIM Proancynol™ per day (there are 40mg of active ingredient per capsule). After one to two weeks, the dosage can be reduced to two capsules per day.


Are the grapes, pine bark, and tea used to make AIM Proancynol™ organically grown?
No. There aren't any pine trees in the world that are organically grown, and very few grapes are, as well. In this instance, how the plants are grown does not effect the product received by the consumer. Because these are very pure extracts, nearing pharmaceutical grade, any impurities that were present in the grape seeds, pine bark or green tea are not present in the finished product.

Are the grape seeds from red or white grapes?
The grape seeds used in AIM Proancynol™ come from both white and red grapes. In terms of active ingredients, both sources are equally valuable. Although it is true that red grapes (not their seeds) contain more OPCs than green grapes, both types of seeds have the same OPC content.

What is the purity of OPCs in AIM Proancynol™?
Each AIM Proancynol™ caplet contains 50mg, with 4Omg proanthocyanidins from grape seed, pine bark, and green tea. This 40mg is 100% extract. The additional 10mg is the fillers needed to package the product, including cellulose (plant fiber) and magnesium stearate (vegetable oil).

Does the green tea contain caffeine?
Most green tea does contain caffeine. However, the green tea used in AIM Proancynol™ is decaffeinated using a water-filtration decaffeination process.

RETAIL: $26.50 Bottle/U.S. - 60 Capsules + Shipping.
WHOLESALE: $23.50 See "How to buy (Wholesale or Retail) link below". Become an AIM Member for $25 and reap the benefits of Wholesale. This information has not been evaluated by the Food and Drug Administration. This product not intended to diagnose, treat, cure, or prevent any disease.

The article "AIM Proancynol™" is reproduced with the permission of AIM International.
©1997 - 1999 by AIM International

Make sure to read the article on Green Tea!

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